POS1445 INCLUSION BODY MYOSITIS ASSOCIATED WITH SJÖGREN SYNDROME HAS DIFFERENT IMMUNE CELLS INFILTRATE FROM SPORADIC INCLUSION BODY MYOSITIS
نویسندگان
چکیده
Background Within the group of inflammatory myopathies, Inclusion-Body Myositis (IBM) is a distinct pathology with clinical and histological features very different from other entities. In literature, an association between primary Sjögren’s syndrome (pSS) IBM has been previously reported. Objectives The aim our study was to compare infiltrates associated or not pSS and, among patients pSS, muscle salivary gland. Methods We conducted translational research project, formalin-fixed paraffin-embedded biopsies IBM, (IBM-pSS) sporadic (sIBM) forms, 6 French expert centers, glands were collected when available. Imaging mass cytometry (IMC) multiplex immunostaining (37 markers) used quantify decipher composition within samples (Figure 1). Supervised unsupervised statistical analyses performed IMC data IBM-pSS sIBM pSS. Results No statistically significant difference encountered in comparisons biopsies. Nevertheless, some trends pointed could merit further work larger case series. Indeed, (14 patients) tended have more widespread infiltrate than (7 involving on average 4.8% versus 1.6% biopsy surface respectively (p=0.12). Macrophages T cells predominant populations both patients’ groups. Among cells, CD8+ predominated compared CD4+ proportion plasma (CD138+ CD38+ CD27+) higher IBMs (medians 14.7% 8.5%, respectively, p=022), as B (median 3.1% 0.5%, p=0.14). Comparing gland numerous less macrophages samples. Nodular pattern containing appeared be restricted Conclusion Using for first time allowed us 1) point sIMB 2) similarities These differences suggest that pSS-related pathophysiology sIBM, which raise potential diagnostic therapeutic applications. Figure 1. Example markers (A) (B) Acknowledgements Société Française de Rhumatologie (French Society Rheumatology) Disclosure Interests None Declared.
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2023
ISSN: ['1468-2060', '0003-4967']
DOI: https://doi.org/10.1136/annrheumdis-2023-eular.3249